Emerging evidence also suggests that the vasculature of women with a prior case of GDM is permanently altered, predisposing them to cardiovascular disease CVD.
This is of major concern, as CVD is the one cause of death in the world [ 60 ]. Child—GDM also Let me fix your needs short- and long-term consequences for the infant. Together, these can cause fetal overgrowth, often resulting in macrosomia at birth [ 61 ].
Macrosomia is also a risk factor for shoulder dystocia—a form of obstructed labor. Thus, babies of GDM pregnancies are usually delivered by caesarean section [ 63Any ladies want a ride ].
Once delivered, these babies are at increased risk of hypoglycemia, which is likely due to formed dependence on maternal hyperglycemia Sexy housewives seeking hot sex Knoxville Tennessee hyperinsulinemiawhich can contribute to brain injury if not properly managed [ 65 ].
There is also evidence that GDM increases the risk of stillbirth [ 66 ].
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Children born to mothers with GDM have almost double the risk of developing childhood obesity when compared with nondiabetic mothers, even after adjusting for confounders such as maternal BMI [ 6768 ], and impaired glucose tolerance can be detected as young as five years old [ 69 ]. Females Alameda CA dating personals therefore more likely to experience GDM in their own pregnancies, contributing to a vicious intergenerational cycle of GDM [ 70 ].
Pathophysiology of Gestational Diabetes The remainder of this review will discuss molecular processes underlying the pathophysiology of GDM. In most cases, these impairments exist prior to pregnancy and can be progressive—representing an increased risk of T2DM post-pregnancy [ 71 ].
A of additional organs and systems contribute to, or are affected by, GDM.
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